Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.65 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.65 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.65 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.65 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.65 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | CCR9 | P51686 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MIF | P14174 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12070491 | 0.81 | POLB (0.63) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL24913589 | 0.79 | CYP3A4 (1.00) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL12368209 | 0.77 | KMT2A (1.00) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL14309048 | 0.77 | KMT2A (0.66) | KMT2APOLBMEN1LMNATP53 | |
| SCHEMBL5426560 | 0.77 | MEN1 (0.74) | KMT2AMEN1LMNATP53MIF | |
| SCHEMBL5380640 | 0.76 | MEN1 (0.57) | KMT2APOLBMEN1LMNATP53 | |
| SCHEMBL5373430 | 0.75 | KMT2A (0.70) | KMT2AMEN1LMNATP53MIF | |
| SCHEMBL13780688 | 0.74 | KMT2A (0.74) | CYP3A4CYP2D6KMT2APOLBMEN1 | |
| SCHEMBL5388038 | 0.74 | MAPT (0.62) | KMT2AMEN1LMNATP53MIF | |
| SCHEMBL5377279 | 0.74 | PTPN1 (0.79) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-20060258723-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PFIZER INC | 2006-11-16 | — | — | US | disclosed |
| US-20050228015-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228015-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | CYP3A4 1922/4885CYP2D6 2484/4885PSEN1 827/4885 |
| US-20060258723-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARG, PPARA, PPARD | CYP3A4 2315/4885CYP2D6 2917/4885PSEN1 1358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.