Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 5/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 3/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.42 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | KIF15 | Q9NS87 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5358637 | 0.95 | ERBB2 (0.51) | ERBB2EGFRIGF1RRAF1LRRK2 | |
| SCHEMBL5358813 | 0.90 | ERBB2 (0.47) | ERBB2EGFRIGF1RRAF1LRRK2 | |
| SCHEMBL5370370 | 0.90 | ERBB2 (0.58) | ERBB2EGFRIGF1RRAF1LRRK2 | |
| SCHEMBL5357662 | 0.88 | ERBB2 (0.61) | ERBB2EGFRIGF1RRAF1LRRK2 | |
| SCHEMBL5358336 | 0.88 | ERBB2 (0.52) | ERBB2EGFRIGF1RRAF1LRRK2 | |
| SCHEMBL5370145 | 0.86 | ERBB2 (0.56) | ERBB2EGFRIGF1RLRRK2PPARG | |
| SCHEMBL5367600 | 0.84 | LRRK2 (0.53) | RAF1LRRK2PPARGPSEN1PSEN2 | |
| SCHEMBL5364965 | 0.84 | ERBB2 (0.63) | ERBB2EGFRIGF1RLRRK2PSEN1 | |
| SCHEMBL5369490 | 0.83 | ERBB2 (0.47) | ERBB2EGFRIGF1RRAF1LRRK2 | |
| SCHEMBL5366594 | 0.82 | ERBB2 (0.57) | ERBB2EGFRIGF1RRAF1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | ERBB2 19/4885EGFR 286/4885IGF1R 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.