Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.74 |
| ▸ | PPARD | Q03181 | 6/20 | 0.74 |
| ▸ | PPARA | Q07869 | 6/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.47 |
| ▸ | RARB | P10826 | 5/20 | 0.47 |
| ▸ | MMP1 | P03956 | 2/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377235 | 1.00 | PPARG (0.74) | PPARGPPARDPPARAMAPTPDE4A | |
| SCHEMBL5375223 | 0.92 | PPARG (0.84) | PPARGPPARDPPARAMAPTMMP1 | |
| SCHEMBL5375212 | 0.92 | PPARG (0.84) | PPARGPPARDPPARAMAPTMMP1 | |
| SCHEMBL5381577 | 0.88 | PPARG (0.82) | PPARGPPARDPPARAMAPTPLA2G4B | |
| SCHEMBL14366511 | 0.88 | PPARG (0.82) | PPARGPPARDPPARAMAPTPLA2G4B | |
| SCHEMBL5375613 | 0.88 | PPARA (0.81) | PPARGPPARDPPARAPLA2G4BRARB | |
| SCHEMBL5375615 | 0.88 | PPARA (0.81) | PPARGPPARDPPARAPLA2G4BRARB | |
| SCHEMBL5374939 | 0.88 | PPARG (0.81) | PPARGPPARDPPARAMAPTMMP1 | |
| SCHEMBL5396260 | 0.88 | PPARG (0.81) | PPARGPPARDPPARAMAPTMMP1 | |
| SCHEMBL14366508 | 0.86 | PPARG (0.78) | PPARGPPARDPPARAMAPTMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070276138-A1 | Modulators of peroxisome proliferator activated receptors | BROOKS DAWN A | 2007-11-29 | — | — | US | disclosed |
| US-7192982-B2 | Modulators of peroxisome proliferator activated receptors | LIGAND PHARMACEUTICALS, INC. (US) | 2007-03-20 | — | — | US | disclosed |
| US-20050020684-A1 | Modulators of peroxisome proliferator activated receptors | ELI LILLY AND COMPANY | 2005-01-27 | — | — | US | disclosed |
| EP-1392637-A2 | MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | ELI LILLY AND COMPANY (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002100813-A2 | MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | ELI LILLY AND COMPANY (US) | 2002-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020684-A1 | Modulators of peroxisome proliferator activated receptors | NCOA4, PPARG, PPARA | PPARG 2/4885PPARD 7/4885PPARA 3/4885 |
| US-20070276138-A1 | Modulators of peroxisome proliferator activated receptors | PPARG, NCOA4, PPARA | PPARG 1/4885PPARD 4/4885PPARA 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.