Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.56 |
| ▸ | TTK | P33981 | 7/20 | 0.55 |
| ▸ | AURKA | O14965 | 8/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.52 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.52 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.48 |
| ▸ | SGK1 | O00141 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5799339 | 0.92 | TTK (0.55) | CSNK1DTTKAURKAAURKBMAP2K4 | |
| SCHEMBL5392302 | 0.84 | AURKA (0.68) | CSNK1DTTKAURKAAURKBMAPK1 | |
| SCHEMBL5397823 | 0.84 | CSNK1D (0.54) | CSNK1DTTKAURKAAURKBMAPK1 | |
| SCHEMBL1460985 | 0.84 | AURKB (0.67) | CSNK1DTTKAURKAAURKBMAPK1 | |
| SCHEMBL5383080 | 0.82 | TTK (0.51) | CSNK1DTTKAURKAAURKBBRD4 | |
| SCHEMBL5381231 | 0.80 | AURKA (0.59) | TTKAURKAMAPK1MAP2K4MAPKAPK3 | |
| SCHEMBL5372788 | 0.79 | AURKA (0.68) | CSNK1DTTKAURKAAURKBMAPK1 | |
| SCHEMBL6797222 | 0.77 | HPGD (0.58) | MAPK1 | |
| SCHEMBL2866791 | 0.77 | MAP2K4 (0.69) | CSNK1DTTKAURKBMAPK1MAP2K4 | |
| SCHEMBL5799264 | 0.76 | AURKA (0.69) | CSNK1DTTKAURKAAURKBMAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211594-B2 | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-05-01 | — | — | US | disclosed |