Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | TOP1 | P11387 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6747185 | 0.82 | ESR1 (0.46) | ESR1ESR2TDP1KMT2AMEN1 | |
| SCHEMBL5217068 | 0.81 | ESR1 (0.47) | ESR1ESR2TDP1KMT2AMEN1 | |
| SCHEMBL5219128 | 0.78 | ESR1 (0.44) | ESR1ESR2TDP1KMT2AMEN1 | |
| SCHEMBL5216396 | 0.77 | ESR1 (0.47) | ESR1ESR2TDP1KMT2AMEN1 | |
| SCHEMBL5217840 | 0.76 | ESR1 (0.43) | ESR1ESR2TDP1KMT2AMEN1 | |
| SCHEMBL5215623 | 0.74 | KMT2A (0.44) | ESR1ESR2TDP1KMT2AMEN1 | |
| SCHEMBL5215071 | 0.74 | ESR1 (0.47) | ESR1ESR2TDP1KMT2AMEN1 | |
| SCHEMBL5218096 | 0.74 | KMT2A (0.41) | ESR1ESR2TDP1KMT2AMEN1 | |
| SCHEMBL5214054 | 0.73 | KMT2A (0.51) | ESR1ESR2TDP1KMT2AMEN1 | |
| SCHEMBL5214926 | 0.72 | ESR1 (0.55) | ESR1ESR2TDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39708-E1 | Estrogen receptor modulators | CHIRON CORPORATION (US) | 2007-06-26 | — | — | US | disclosed |
| US-6291505-B1 | PYRAZOLE ESTROGEN RECEPTOR AGONIST AND ANTAGONIST | CHIRON CORPORATION | 2001-09-18 | — | — | US | disclosed |