Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 18/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.67 |
| ▸ | CDK1 | P06493 | 4/20 | 0.58 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.58 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.57 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.57 |
| ▸ | CDK7 | P50613 | 2/20 | 0.57 |
| ▸ | CDK9 | P50750 | 2/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.57 |
| ▸ | CDK4 | P11802 | 1/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.57 |
| ▸ | CCND1 | P24385 | 1/20 | 0.57 |
| ▸ | CCND3 | P30281 | 1/20 | 0.57 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.57 |
| ▸ | GSK3A | P49840 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548674 | 0.94 | CDK2 (0.80) | CDK2KCNH2CDK1CCNB1CCNA2 | |
| SCHEMBL3551055 | 0.84 | CDK2 (1.00) | CDK2KCNH2CDK1CCNB1CCNA2 | |
| SCHEMBL4254089 | 0.83 | CDK4 (0.68) | CDK2KCNH2CDK1CCNB1CCNA2 | |
| Hydrochloric Acid SCHEMBL3549634 | 0.80 | CDK2 (0.59) | CDK2KCNH2CDK1CCNB1CCNA2 | |
| SCHEMBL3555947 | 0.80 | KCNH2 (1.00) | CDK2KCNH2CDK1CCNB1CCNA2 | |
| SCHEMBL3549598 | 0.80 | CDK2 (0.83) | CDK2KCNH2CDK1CCNB1CCNA2 | |
| SCHEMBL3548656 | 0.78 | CDK2 (1.00) | CDK2KCNH2CDK1CCNB1CCNA2 | |
| SCHEMBL3556925 | 0.78 | CDK2 (0.64) | CDK2KCNH2CDK1CCNB1CCNA2 | |
| SCHEMBL3551129 | 0.77 | CDK2 (0.85) | CDK2KCNH2CDK1CCNB1CCNA2 | |
| SCHEMBL3543951 | 0.77 | KCNH2 (0.81) | CDK2KCNH2CDK1CCNB1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |