Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5379383 | 0.93 | MAPT (0.40) | MAPTKDM4ESMN1; SMN2RXFP1RAB9A | |
| SCHEMBL5387609 | 0.92 | KDM4E (0.40) | MAPTKDM4ESMN1; SMN2RXFP1RAB9A | |
| SCHEMBL5387466 | 0.89 | MAPT (0.44) | MAPTKDM4ESMN1; SMN2RXFP1RAB9A | |
| SCHEMBL5379340 | 0.88 | MAPT (0.34) | MAPTKDM4ESMN1; SMN2RXFP1RAB9A | |
| SCHEMBL5381841 | 0.84 | KDM4E (0.41) | MAPTKDM4ESMN1; SMN2RXFP1RAB9A | |
| SCHEMBL5374629 | 0.82 | PPARG (0.46) | ALDH1A1LMNAPPARGPPARDPPARA | |
| SCHEMBL5371988 | 0.82 | KDM4E (0.44) | MAPTKDM4ERAB9AGAALMNA | |
| SCHEMBL5392101 | 0.81 | CYSLTR2 (0.41) | ALDH1A1CYSLTR2CYSLTR1PPARGPPARD | |
| SCHEMBL5393683 | 0.80 | PDE4B (0.35) | MAPTKDM4ESMN1; SMN2RXFP1RAB9A | |
| SCHEMBL5381156 | 0.79 | CYP4F2 (0.44) | KDM4EGAAALDH1A1LMNACYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |
| EP-1457490-A1 | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity | Takeda Chemical Industries, Ltd. (JP) | 2004-09-15 | — | — | EP | disclosed |
| EP-1228067-B1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-07-14 | — | — | EP | disclosed |