Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL538219 | 0.80 | AKT1 (0.59) | AKT1AKT2 | |
| SCHEMBL868528 | 0.76 | AKT1 (0.62) | AKT1AKT2 | |
| SCHEMBL538262 | 0.72 | AKT1 (0.59) | AKT1 | |
| SCHEMBL868271 | 0.72 | AKT1 (0.55) | AKT1AKT2 | |
| SCHEMBL866643 | 0.68 | AKT1 (0.74) | AKT1AKT2 | |
| SCHEMBL867445 | 0.68 | AKT1 (0.52) | AKT1AKT2 | |
| SCHEMBL360523 | 0.68 | AKT1 (1.00) | AKT1AKT2 | |
| SCHEMBL538786 | 0.67 | AKT1 (0.66) | AKT1AKT2 | |
| SCHEMBL866319 | 0.67 | AKT1 (0.53) | AKT1AKT2 | |
| SCHEMBL538567 | 0.67 | AKT1 (0.68) | AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413932-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114780-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |