SCHEMBL5384708

SCHEMBL5384708

CN(C)c1cccc2c(S(=O)(=O)NCCCCN)cccc12

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.67
HDAC10 Q969S8 1/20 0.67
HDAC6 Q9UBN7 1/20 0.67
HDAC5 Q9UQL6 1/20 0.67
CYP3A4 P08684 5/20 0.66
CYP1A2 P05177 4/20 0.66
CYP2C9 P11712 4/20 0.66
CYP2C19 P33261 4/20 0.66
TP53 P04637 4/20 0.66
CYP2D6 P10635 3/20 0.66
MAPK1 P28482 3/20 0.66
THPO P40225 2/20 0.66
NFKB1 P19838 1/20 0.66
MEN1 O00255 3/20 0.64
KMT2A Q03164 3/20 0.64
TSHR P16473 2/20 0.64
ALDH1A1 P00352 2/20 0.64
GMNN O75496 2/20 0.64
LMNA P02545 2/20 0.64
PMP22 Q01453 2/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17312330 0.99 HDAC4 (0.69) HDAC4HDAC10HDAC6HDAC5CYP3A4
SCHEMBL107806 0.99 HDAC4 (0.69) HDAC4HDAC10HDAC6HDAC5CYP3A4
SCHEMBL29729303 0.99 HDAC4 (0.69) HDAC4HDAC10HDAC6HDAC5CYP3A4
SCHEMBL107807 0.99 HDAC4 (0.69) HDAC4HDAC10HDAC6HDAC5CYP3A4
SCHEMBL6361662 0.99 HDAC4 (0.69) HDAC4HDAC10HDAC6HDAC5CYP3A4
SCHEMBL8488157 0.96 HDAC4 (0.65) HDAC4HDAC10HDAC6HDAC5CYP3A4
SCHEMBL4126349 0.95 HDAC4 (0.62) HDAC4HDAC10HDAC6HDAC5CYP3A4
SCHEMBL28265897 0.94 HDAC4 (0.64) HDAC4HDAC10HDAC6HDAC5CYP3A4
SCHEMBL4139459 0.93 HDAC4 (0.75) HDAC4HDAC10HDAC6HDAC5CYP3A4
SCHEMBL28267305 0.93 CYP3A4 (0.63) HDAC4HDAC10HDAC6HDAC5CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3442533-A1 TG2 INHIBITOR COMPOUNDS AND USES THEREOF University Of Ottawa (CA) 2019-02-20 EP disclosed
WO-2017179018-A1 TG2 INHIBITOR COMPOUNDS AND USES THEREOF UNIVERSITY OF OTTAWA (CA) 2017-10-19 WO disclosed
EP-1867633-A1 Polyamine analogues as therapeutic and diagnostic agents MediQuest Therapeutics, Inc. (US) 2007-12-19 EP disclosed
US-7232846-B2 Amines as anti-alcoholism agents GARBIL PHARMA INVESTIGACION CHILE LTDA. 2007-06-19 US disclosed
US-7160923-B1 Polyamine analogues as therapeutic and diagnostic agents MEDIQUEST THERAPEUTICS, INC. (US) 2007-01-09 US disclosed
CN-1575494-A Product packaging including digital data VERIFICATION TECHNOLOGIES INC (US) 2005-02-02 CN disclosed
EP-1437133-A1 AMINES WITH ANTIALCOHOLIC AGENTS Garbil Pharma Investigacion Chile Ltda. (CL) 2004-07-14 EP disclosed
US-6172261-B1 BIOSYNTHESIS USING CHAIN EXTENSION ORIDIGM CORPORATION 2001-01-09 US disclosed
EP-1001927-A2 NOVEL POLYAMINE ANALOGUES AS THERAPEUTIC AND DIAGNOSTIC AGENTS ORIDIGM CORPORATION (US) 2000-05-24 EP disclosed
WO-1999003823-A2 NOVEL POLYAMINE ANALOGUES AS THERAPEUTIC AND DIAGNOSTIC AGENTS ORIDIGM CORPORATION (US) 1999-01-28 WO disclosed