Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 1/20 | 0.53 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | LAP3 | P28838 | 3/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.37 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5222286 | 0.99 | CSNK1E (0.52) | CSNK1EF2TRPA1BCHEEPHX1 | |
| SCHEMBL5390344 | 0.95 | CSNK1E (0.51) | CSNK1EF2TRPA1BCHEEPHX1 | |
| SCHEMBL5385780 | 0.95 | CSNK1E (0.51) | CSNK1EF2TRPA1BCHEEPHX1 | |
| Hydrochloric Acid SCHEMBL5224199 | 0.94 | CSNK1E (0.50) | CSNK1EF2TRPA1BCHEEPHX1 | |
| Hydrochloric Acid SCHEMBL5225719 | 0.94 | CSNK1E (0.50) | CSNK1EF2TRPA1BCHEEPHX1 | |
| SCHEMBL4688261 | 0.94 | CSNK1E (0.50) | CSNK1EF2TRPA1BCHEEPHX1 | |
| Hydrochloric Acid SCHEMBL5219524 | 0.93 | CSNK1E (0.49) | CSNK1EF2TRPA1BCHEEPHX1 | |
| SCHEMBL4690000 | 0.89 | CSNK1E (0.49) | CSNK1EF2TRPA1EPHX1LAP3 | |
| Hydrochloric Acid SCHEMBL5221629 | 0.88 | CSNK1E (0.48) | CSNK1EF2TRPA1EPHX1LAP3 | |
| Hydrochloric Acid SCHEMBL5220486 | 0.86 | CSNK1E (0.47) | CSNK1EF2TRPA1BCHEEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253198-B2 | Hydroxyethylamine derivatives for the treatment of Alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2007-08-07 | — | — | US | disclosed |
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | BACE2, PSEN2, BACE1 | CSNK1E 1649/4885F2 4696/4885TRPA1 4648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.