Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.79 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.56 |
| ▸ | CDK2AP1 | O14519 | 7/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4212966 | 1.00 | CHEK1 (0.79) | CHEK1CHRNB2CHRNA4CDK2AP1 | |
| Hydrochloric Acid SCHEMBL4212738 | 0.99 | CHEK1 (0.78) | CHEK1CHRNB2CHRNA4CDK2AP1 | |
| SCHEMBL5394578 | 0.97 | CHEK1 (0.75) | CHEK1CHRNB2CHRNA4CDK2AP1 | |
| SCHEMBL4216725 | 0.97 | CHEK1 (0.75) | CHEK1CHRNB2CHRNA4CDK2AP1 | |
| Hydrochloric Acid SCHEMBL4218123 | 0.96 | CHEK1 (0.74) | CHEK1CHRNB2CHRNA4CDK2AP1 | |
| SCHEMBL4702698 | 0.89 | CHEK1 (0.66) | CHEK1CDK2AP1 | |
| SCHEMBL4215526 | 0.89 | CHEK1 (0.66) | CHEK1CDK2AP1 | |
| SCHEMBL4212807 | 0.89 | CHEK1 (0.66) | CHEK1CDK2AP1 | |
| SCHEMBL4208325 | 0.89 | CHEK1 (0.64) | CHEK1CDK2AP1 | |
| SCHEMBL1563248 | 0.89 | CHEK1 (1.00) | CHEK1CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007502308-A | — | — | 2007-02-08 | — | — | JP | claimed |
| EP-1660474-A1 | SUBSTITUTED THIOPHENES AND USES THEREOF | AstraZeneca AB (SE) | 2006-05-31 | — | — | EP | claimed |
| WO-2005016909-A1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-02-24 | — | — | WO | claimed |
| EP-1660474-A1 | SUBSTITUTED THIOPHENES AND USES THEREOF | AstraZeneca AB (SE) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005016909-A1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-02-24 | — | — | WO | disclosed |