Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 14/20 | 0.54 |
| ▸ | PLK1 | P53350 | 5/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5395239 | 0.82 | IKBKE (0.43) | IKBKEPLK1TBK1 | |
| SCHEMBL4032176 | 0.76 | IKBKE (0.90) | IKBKEPLK1TBK1 | |
| SCHEMBL4035642 | 0.63 | IKBKE (0.95) | IKBKEPLK1TBK1 | |
| SCHEMBL4035220 | 0.59 | PLK1 (1.00) | IKBKEPLK1 | |
| SCHEMBL13475569 | 0.56 | HPGD (0.49) | — | |
| SCHEMBL12593176 | 0.54 | HPGD (0.44) | — | |
| SCHEMBL19473156 | 0.53 | HPGD (0.49) | — | |
| SCHEMBL6941777 | 0.53 | AR (0.49) | — | |
| SCHEMBL14220732 | 0.52 | NPC1 (0.58) | — | |
| SCHEMBL14084720 | 0.52 | PARP15 (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007522142-A | — | — | 2007-08-09 | — | — | JP | claimed |
| EP-1720864-A1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON IKK3 | GLAXO GROUP LIMITED (GB) | 2006-11-15 | — | — | EP | claimed |
| WO-2005075465-A1 | BENZIMIDAZOL SUBSTITUTED THIOPENE DERIVATIVES WITH ATCTIVITY ON IKK3 | GLAXO GROUP LIMITED (GB) | 2005-08-18 | — | — | WO | claimed |