⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL478029 | 1.00 | — | — | |
| SCHEMBL537514 | 1.00 | — | — | |
| SCHEMBL1736432 | 0.95 | — | — | |
| SCHEMBL10961802 | 0.74 | — | — | |
| SCHEMBL10961805 | 0.74 | — | — | |
| SCHEMBL25381253 | 0.74 | — | — | |
| SCHEMBL6294842 | 0.74 | — | — | |
| SCHEMBL554911 | 0.74 | — | — | |
| SCHEMBL554910 | 0.74 | — | — | |
| SCHEMBL7135962 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112047870-B | Preparation method of 7-alkyl indole derivative | 浙江工业大学 | 2021-10-12 | — | — | CN | claimed |
| CN-112047870-A | Preparation method of 7-alkyl indole derivative | 浙江工业大学 | 2020-12-08 | — | — | CN | claimed |
| US-20240261288-A1 | COMBINATION OF A 3-(IMIDAZOL-4-YL)-4-(AMINO)-BENZENESULFONAMIDE TEAD INHIBITOR WITH AN EGFR INHIBITOR AND/OR MEK INHIBITOR FOR USE IN THE TREATMENT OF LUNG CANCER | THE EHE FOUNDATION | 2024-08-08 | — | — | US | disclosed |
| CN-117561061-A | Combination of 3- (imidazol-4-yl) -4- (amino) -benzenesulfonamide TEAD inhibitors with EGFR inhibitors and/or MEK inhibitors for the treatment of lung cancer | 医肯纳肿瘤学公司 | 2024-02-13 | — | — | CN | disclosed |
| WO-2023122754-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING GB13, GB22 AND HIMGALINE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-06-29 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| US-11332426-B2 | Method of preparing trisubstituted ethylene compounds | TRUSTEES OF BOSTON COLLEGE (US) | 2022-05-17 | — | — | US | disclosed |
| CN-112047870-B | Preparation method of 7-alkyl indole derivative | 浙江工业大学 | 2021-10-12 | — | — | CN | disclosed |
| CN-112174787-A | Preparation method of trans-2-methyl-2-butenal | 浙江凯普化工有限公司 | 2021-01-05 | — | — | CN | disclosed |
| CN-112174787-A | Preparation method of trans-2-methyl-2-butenal | 浙江凯普化工有限公司 | 2021-01-05 | — | — | CN | disclosed |
| US-7285410-B2 | Preparation of (E)- and (Z)-2-methyl-2-butenoic acids | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-10-23 | — | — | US | disclosed |
| US-7220562-B2 | Preparation of (E)- and (Z)-2-methyl-2-butenoic acids | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-05-22 | — | — | US | disclosed |
| US-7198926-B2 | Preparation of (E)- and (Z)-2-methyl-2-butenoic acids | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-04-03 | — | — | US | disclosed |
| US-20070037264-A1 | Using trangenic microorganism having nitrilase and amidase activities to convert (E,Z)-2-methyl-2-butenenitrile into (E and Z)-2-methyl-2-butenoic acids | BRAMUCCI MICHAEL G | 2007-02-15 | — | — | US | disclosed |
| US-20060115883-A1 | Preparation of (E)- and (Z)-2-methyl-2-butenoic acids | BRAMUCCI MICHAEL G | 2006-06-01 | — | — | US | disclosed |
| WO-2004101513-A2 | PREPARATION OF (E)- AND (Z)-2-METHYL-2-BUTENOIC ACIDS | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2004-11-25 | — | — | WO | disclosed |
| US-20040224395-A1 | Preparation of (E)- and (Z)-2-methyl-2-butenoic acids | E. I. DU PONT DE NEMOURS AND COMPANY | 2004-11-11 | — | — | US | disclosed |
| US-5245064-A | Catlaysis | GASSMAN PAUL G (US) | 1993-09-14 | — | — | US | disclosed |
| US-4827004-A | ANTIULCER AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1989-05-02 | — | — | US | disclosed |