SCHEMBL5397398

SCHEMBL5397398

CC(C)COc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccc(CC=O)cc1)C2

nearest known ligand 0.68

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CCR8 P51685 9/20 0.68
KCNH2 Q12809 9/20 0.68
CYP2D6 P10635 10/20 0.53
USP2 O75604 3/20 0.53
CYP3A4 P08684 6/20 0.51
TSHR P16473 3/20 0.51
ALDH1A1 P00352 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL5777024 0.95 CCR8 (0.62) CCR8KCNH2CYP2D6USP2CYP3A4
SCHEMBL5392214 0.95 CCR8 (0.68) CCR8KCNH2CYP2D6USP2CYP3A4
SCHEMBL5413974 0.91 CCR8 (0.70) CCR8KCNH2CYP2D6USP2CYP3A4
Trifluoroacetic Acid SCHEMBL5779040 0.90 CCR8 (0.62) CCR8KCNH2CYP2D6USP2CYP3A4
SCHEMBL5395604 0.89 CCR8 (0.68) CCR8KCNH2CYP2D6USP2CYP3A4
SCHEMBL5402026 0.89 CCR8 (0.73) CCR8KCNH2CYP2D6USP2CYP3A4
SCHEMBL5397396 0.89 CCR8 (0.73) CCR8KCNH2CYP2D6USP2CYP3A4
SCHEMBL5404965 0.88 CCR8 (0.72) CCR8KCNH2CYP2D6USP2CYP3A4
SCHEMBL5402122 0.87 CYP2D6 (0.71) CCR8KCNH2CYP2D6USP2CYP3A4
SCHEMBL5405018 0.87 CCR8 (0.89) CCR8KCNH2CYP2D6USP2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2007509141-A 2007-04-12 JP claimed
EP-1678178-A1 NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES AstraZeneca AB (SE) 2006-07-12 EP claimed
WO-2005040167-A1 NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES ASTRAZENECA AB (SE) 2005-05-06 WO claimed
EP-1678178-A1 NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES AstraZeneca AB (SE) 2006-07-12 EP disclosed
WO-2005040167-A1 NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES ASTRAZENECA AB (SE) 2005-05-06 WO disclosed