Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 17/20 | 0.49 |
| ▸ | PPARA | Q07869 | 16/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5376885 | 0.94 | FFAR1 (0.56) | PPARGPPARAFFAR1KDR | |
| SCHEMBL5382054 | 0.92 | PPARG (0.49) | PPARGPPARAFFAR1KDR | |
| SCHEMBL5371978 | 0.90 | FFAR1 (0.57) | PPARGPPARAFFAR1KDR | |
| SCHEMBL5385871 | 0.87 | FFAR1 (0.43) | PPARGPPARAFFAR1KDR | |
| SCHEMBL5376899 | 0.87 | FFAR1 (0.60) | PPARGPPARAFFAR1KDR | |
| SCHEMBL5377278 | 0.87 | FFAR1 (0.47) | PPARGPPARAFFAR1KDR | |
| SCHEMBL5383071 | 0.86 | KDR (0.56) | PPARGPPARAFFAR1KDR | |
| SCHEMBL5376749 | 0.86 | FFAR1 (0.45) | PPARGPPARAFFAR1KDR | |
| SCHEMBL5380604 | 0.85 | FFAR1 (0.56) | PPARGPPARAFFAR1KDR | |
| SCHEMBL5372574 | 0.85 | PPARG (0.48) | PPARGPPARAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |
| EP-1457490-A1 | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity | Takeda Chemical Industries, Ltd. (JP) | 2004-09-15 | — | — | EP | disclosed |
| EP-1228067-B1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-07-14 | — | — | EP | disclosed |
| EP-1228067-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY | Takeda Chemical Industries, Ltd. (JP) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001038325-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-31 | — | — | WO | disclosed |