Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 2,4-Dichlorophenoxyacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.94 |
| ▸ | TSHR | P16473 | 1/20 | 0.94 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | PPARD | Q03181 | 1/20 | 0.56 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2,4-Dichlorophenoxyacetic Acid SCHEMBL158138 | 0.97 | TDP1 (1.00) | TDP1TSHRSMN1; SMN2MEN1KMT2A | |
| 2,4-Dichlorophenoxyacetic Acid SCHEMBL9578938 | 0.97 | TDP1 (1.00) | TDP1TSHRSMN1; SMN2MEN1KMT2A | |
| 2,4-Dichlorophenoxyacetic Acid SCHEMBL16197647 | 0.97 | TDP1 (1.00) | TDP1TSHRSMN1; SMN2MEN1KMT2A | |
| 2,4-Dichlorophenoxyacetic Acid SCHEMBL11224813 | 0.95 | TDP1 (0.97) | TDP1TSHRSMN1; SMN2MEN1KMT2A | |
| 2,4-Dichlorophenoxyacetic Acid SCHEMBL22557994 | 0.94 | TDP1 (0.89) | TDP1TSHRSMN1; SMN2MEN1KMT2A | |
| 2,4-Dichlorophenoxyacetic Acid SCHEMBL23250565 | 0.93 | TDP1 (0.91) | TDP1TSHRSMN1; SMN2MEN1KMT2A | |
| 2,4-Dichlorophenoxyacetic Acid SCHEMBL17203456 | 0.93 | TDP1 (0.91) | TDP1TSHRSMN1; SMN2MEN1KMT2A | |
| 2,4-Dichlorophenoxyacetic Acid SCHEMBL3397959 | 0.93 | TDP1 (0.91) | TDP1TSHRSMN1; SMN2MEN1KMT2A | |
| 2,4-Dichlorophenoxyacetic Acid SCHEMBL23250675 | 0.91 | TDP1 (0.89) | TDP1TSHRSMN1; SMN2MEN1KMT2A | |
| 2,4-Dichlorophenoxyacetic Acid SCHEMBL9403549 | 0.91 | TDP1 (0.89) | TDP1TSHRSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423469-A1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES AS HTRA1 INHIBITORS | H. Hoffnabb-La Roche Ag (CH) | 2019-01-09 | — | — | EP | disclosed |
| JP-2007320305-A | SHAPING METHOD FOR PRESERVED FLOWER ARRANGEMENT | KUWAJIMA YOSHIHIDE | 2007-12-13 | — | — | JP | disclosed |