Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4332999 | 0.91 | KDR (0.51) | KMT2AKDREPHB4TEKMAPT | |
| SCHEMBL4324533 | 0.90 | KMT2A (0.41) | KMT2AKDREPHB4TEKMAPT | |
| SCHEMBL4328559 | 0.81 | EPHB4 (0.51) | KMT2AKDREPHB4TEKMAPT | |
| SCHEMBL4330725 | 0.81 | MAPT (0.56) | KMT2AEPHB4MAPTMEN1SMN1; SMN2 | |
| SCHEMBL4323333 | 0.81 | EPHB4 (0.46) | KMT2AKDREPHB4TEKMAPT | |
| SCHEMBL4333755 | 0.80 | EPHB4 (0.48) | KMT2AKDREPHB4TEKMAPT | |
| SCHEMBL4321433 | 0.80 | KMT2A (0.52) | KMT2AEPHB4MAPTMEN1SMN1; SMN2 | |
| SCHEMBL4321789 | 0.79 | CYP1A2 (0.49) | KMT2AKDREPHB4TEKMAPT | |
| SCHEMBL4318354 | 0.78 | RAF1 (0.55) | KDREPHB4TEKMAPTSMN1; SMN2 | |
| SCHEMBL4331851 | 0.78 | MAPT (0.53) | KMT2AKDREPHB4MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858877-A1 | 1,3 SUBSTITUTED DIARYL UREAS AS MODULATORS OF KINASE ACTIVITY | CGI Pharmaceuticals, Inc. (US) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006076592-A1 | 1,3 SUBSTITUTED DIARYL UREAS AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. (US) | 2006-07-20 | — | — | WO | disclosed |