Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.54 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 3/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4028983 | 0.88 | ESR1 (0.70) | ESR1RORCSSTR4HPGDPPARG | |
| SCHEMBL4027587 | 0.82 | ESR1 (0.53) | ESR1NR1H2NR1H3ALDH1A1LMNA | |
| SCHEMBL13106136 | 0.79 | SSTR4 (0.44) | ESR1NR1H2NR1H3HSD11B1SSTR4 | |
| SCHEMBL13202563 | 0.79 | SSTR4 (0.44) | ESR1NR1H2NR1H3ALDH1A1HSD11B1 | |
| SCHEMBL4027869 | 0.76 | ESR1 (0.65) | ESR1SSTR4SMN1; SMN2 | |
| SCHEMBL29941523 | 0.75 | ESR1 (0.66) | ESR1NR1H2NR1H3ALDH1A1LMNA | |
| SCHEMBL21067954 | 0.75 | ESR1 (0.66) | ESR1NR1H2NR1H3ALDH1A1LMNA | |
| SCHEMBL16252840 | 0.74 | SSTR4 (0.41) | ESR1NR1H2NR1H3ALDH1A1HSD11B1 | |
| SCHEMBL16252859 | 0.74 | SSTR4 (0.51) | ESR1NR1H2NR1H3HSD11B1SSTR4 | |
| SCHEMBL15631890 | 0.73 | KMT2A (0.65) | ESR1NR1H2NR1H3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241791-B2 | Substituted 4-(indazol-3-yl)phenols | WYETH (US) | 2007-07-10 | — | — | US | disclosed |