Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TOP1 | P11387 | 2/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 3/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.33 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | FABP6 | P51161 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12225649 | 0.83 | MEN1 (0.40) | LRRK2KMT2AMEN1TOP1RPS6KA3 | |
| SCHEMBL2199212 | 0.83 | MEN1 (0.40) | LRRK2KMT2AMEN1TOP1RPS6KA3 | |
| SCHEMBL2199214 | 0.83 | MEN1 (0.40) | LRRK2KMT2AMEN1TOP1RPS6KA3 | |
| SCHEMBL2199443 | 0.81 | MAPK14 (0.42) | LRRK2KMT2AMEN1TOP1RPS6KA3 | |
| SCHEMBL12225647 | 0.81 | MAPK14 (0.42) | LRRK2KMT2AMEN1TOP1RPS6KA3 | |
| SCHEMBL2199448 | 0.81 | MAPK14 (0.42) | LRRK2KMT2AMEN1TOP1RPS6KA3 | |
| SCHEMBL6087391 | 0.77 | KMT2A (0.46) | LRRK2KMT2AMEN1TOP1RPS6KA3 | |
| SCHEMBL6087395 | 0.77 | KMT2A (0.46) | LRRK2KMT2AMEN1TOP1RPS6KA3 | |
| SCHEMBL2201338 | 0.77 | ALK (0.38) | LRRK2KMT2AMEN1TOP1RPS6KA3 | |
| SCHEMBL2201334 | 0.77 | ALK (0.38) | LRRK2KMT2AMEN1TOP1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007109596-A2 | HETEROARYL DIHYDROINDOLONES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2007-09-27 | — | — | WO | disclosed |