Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 15/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5406374 | 0.91 | MAP2K1 (0.36) | MAP2K1DGAT1TP53MAP2K2MAPK1 | |
| SCHEMBL3972766 | 0.91 | MAP2K1 (0.35) | MAP2K1DGAT1KDM4ETP53TSHR | |
| SCHEMBL5393091 | 0.89 | FLT1 (0.37) | MAP2K1KDM4EMAP2K2 | |
| SCHEMBL14499764 | 0.86 | MAP2K1 (0.34) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL5399041 | 0.86 | MAP2K2 (0.34) | MAP2K1MAP2K2 | |
| SCHEMBL5403319 | 0.85 | MAP2K1 (0.33) | MAP2K1KDM4ETP53TSHRHSD17B10 | |
| SCHEMBL3979555 | 0.83 | KDR (0.36) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL3973256 | 0.82 | MAP2K1 (0.34) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL3974741 | 0.81 | MAP2K1 (0.39) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL3976169 | 0.79 | MAP2K1 (0.36) | MAP2K1KDM4ETP53TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230099-B2 | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA, INC. (US) | 2007-06-12 | — | — | US | claimed |
| EP-1673339-B1 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2013-07-03 | — | — | EP | disclosed |