Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 4/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 6/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 6/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5401149 | 0.84 | CCNE2 (0.41) | PRMT5WDR77FLT3GABRA1GABRG2 | |
| SCHEMBL5406212 | 0.78 | PRMT5 (0.47) | PRMT5WDR77GABRA1GABRG2GABRB3 | |
| SCHEMBL5405186 | 0.77 | FLT3 (0.52) | HASPINKITPIM1FLT3CDK7 | |
| SCHEMBL5412317 | 0.76 | FLT3 (0.46) | PRMT5WDR77HASPINFLT3SMN1; SMN2 | |
| SCHEMBL5399692 | 0.74 | CCNE1 (0.38) | PRMT5WDR77PIM1FLT3DPP4 | |
| SCHEMBL5403389 | 0.74 | CCNE2 (0.41) | PRMT5WDR77FLT3DPP4SMN1; SMN2 | |
| SCHEMBL5404980 | 0.73 | MAPT (0.41) | DPP4GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL5618295 | 0.72 | TTK (0.36) | PRMT5WDR77SMN1; SMN2L3MBTL1 | |
| SCHEMBL5400802 | 0.72 | PRMT5 (0.43) | PRMT5WDR77SMN1; SMN2L3MBTL1 | |
| SCHEMBL5401418 | 0.71 | KDM4E (0.43) | PRMT5WDR77SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009832-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN, INC. | 2005-01-13 | — | — | US | claimed |
| US-20040220189-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhbitors | SUGEN, INC. | 2004-11-04 | — | — | US | claimed |
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7157460-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-20050009832-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN, INC. | 2005-01-13 | — | — | US | disclosed |
| US-20040220189-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhbitors | SUGEN, INC. | 2004-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009832-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | MAP3K8, MAP3K2, MAP3K5 | PRMT5 728/4885WDR77 2178/4885HASPIN 517/4885 |
| US-20040220189-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhbitors | MAP3K8, MAP4K4, MAP3K2 | PRMT5 1599/4885WDR77 3638/4885HASPIN 301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.