Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | F13A1 | P00488 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | TGM1 | P22735 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5415161 | 0.83 | HTT (0.49) | SMN1; SMN2CYP2C19NPC1RAB9ACHRM4 | |
| SCHEMBL5407046 | 0.73 | SMN1; SMN2 (0.35) | SMN1; SMN2CYP2C19CYP2D6NPSR1 | |
| SCHEMBL5407039 | 0.73 | SMN1; SMN2 (0.35) | SMN1; SMN2CYP2C19CYP2D6NPSR1 | |
| SCHEMBL7375294 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2CYP2C19NPC1RAB9ACHRM4 | |
| SCHEMBL7370753 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2CYP2C19NPC1RAB9ACHRM4 | |
| SCHEMBL7369584 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2CYP2C19NPC1RAB9ACHRM4 | |
| SCHEMBL15140566 | 0.73 | SMN1; SMN2 (0.72) | SMN1; SMN2CYP2C19NPC1RAB9ACHRM4 | |
| SCHEMBL7291714 | 0.72 | SMN1; SMN2 (0.61) | SMN1; SMN2CYP2C19NPC1RAB9ACHRM4 | |
| SCHEMBL29384528 | 0.72 | SMN1; SMN2 (0.56) | SMN1; SMN2CYP2C19NPC1RAB9ACHRM4 | |
| SCHEMBL8553423 | 0.72 | SMN1; SMN2 (0.68) | SMN1; SMN2CYP2C19NPC1RAB9ACHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7247645-B2 | Dihydropyridine derivatives | AJINOMOTO CO., INC. (JP) | 2007-07-24 | — | — | US | disclosed |
| US-20020147222-A1 | Dihydropyridine derivatives | AJINOMOTO CO. INC (JP) | 2002-10-10 | — | — | US | disclosed |
| EP-1191021-A1 | DIHYDROPYRIDINE DERIVATIVE | Ajinomoto Co., Inc. (JP) | 2002-03-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020147222-A1 | Dihydropyridine derivatives | CACNA1B, CACNA1D, CACNA1C | SMN1; SMN2 331/4885CYP2C19 2829/4885NPC1 429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.