Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.44 |
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | SGK1 | O00141 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5408010 | 0.87 | AXL (0.40) | AXLTYRO3MERTKROCK2CCR2 | |
| SCHEMBL5413298 | 0.86 | AXL (0.45) | AXLTYRO3MERTKMAOAMAOB | |
| SCHEMBL5405638 | 0.86 | HRH3 (0.42) | AXLTYRO3MERTKHRH3 | |
| SCHEMBL5414878 | 0.86 | AXL (0.45) | AXLTYRO3MERTKMAOAMAOB | |
| SCHEMBL5401813 | 0.85 | AXL (0.43) | AXLTYRO3MERTKMAOAMAOB | |
| SCHEMBL5412679 | 0.85 | HRH3 (0.47) | AXLTYRO3MERTKHRH3 | |
| SCHEMBL5417439 | 0.84 | CYP4F2 (0.47) | AXLTYRO3MERTKTIPARPPIK3CA | |
| SCHEMBL5413106 | 0.83 | AXL (0.42) | AXLTYRO3MERTKTIPARPTGFBR1 | |
| SCHEMBL5410905 | 0.82 | AXL (0.43) | AXLTYRO3MERTKTIPARP | |
| SCHEMBL5410993 | 0.82 | AXL (0.43) | AXLTYRO3MERTKTIPARP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199147-B2 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-04-03 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |