Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | ACP1 | P24666 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL398344 | 0.86 | ACP1 (0.40) | ACACBACACACHEK2ACP1HTR2B | |
| SCHEMBL396480 | 0.84 | BTK (0.35) | IGF1RACP1HTR2B | |
| SCHEMBL401369 | 0.83 | TNK2 (0.34) | IGF1RACP1HTR2BCYP3A4 | |
| SCHEMBL402711 | 0.82 | ACACB (0.37) | ACACBACACAACP1CYP3A4 | |
| SCHEMBL401671 | 0.82 | ACP1 (0.35) | IGF1RACP1HTR2B | |
| SCHEMBL400428 | 0.82 | GRIN2B (0.44) | GRIN2BACP1CYP3A4 | |
| SCHEMBL3047394 | 0.80 | ACP1 (0.42) | IGF1RACACBACACAACP1HTR2B | |
| SCHEMBL399702 | 0.80 | ACP1 (0.39) | IGF1RACP1CYP3A4 | |
| SCHEMBL1315711 | 0.78 | IGF1R (0.32) | IGF1RCYP3A4 | |
| SCHEMBL398046 | 0.78 | PDE10A (0.35) | IGF1RACACBACACAACP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740591-A1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005097800-A1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-10-20 | — | — | WO | disclosed |