Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.49 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766953 | 0.92 | AURKA (0.57) | EGFRAURKARPS6KB1ERBB2GRM1 | |
| SCHEMBL7496670 | 0.87 | EGFR (0.62) | EGFRAURKARPS6KB1ERBB2GRM1 | |
| SCHEMBL4764369 | 0.86 | EGFR (0.52) | EGFRERBB2 | |
| SCHEMBL7492081 | 0.85 | EGFR (0.58) | EGFRERBB2CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL4772678 | 0.84 | EGFR (0.55) | EGFRAURKARPS6KB1GRM1 | |
| SCHEMBL4764395 | 0.83 | EGFR (0.52) | EGFRAURKARPS6KB1ERBB2GRM1 | |
| SCHEMBL4765608 | 0.83 | EGFR (0.52) | EGFRAURKARPS6KB1ERBB2GRM1 | |
| SCHEMBL27603144 | 0.82 | KDR (0.61) | EGFRAURKARPS6KB1ERBB2CSNK2A1 | |
| SCHEMBL4764461 | 0.82 | EGFR (0.52) | EGFRAURKARPS6KB1ERBB2HDAC3 | |
| SCHEMBL4767296 | 0.81 | EGFR (0.53) | EGFRAURKAERBB2GRM1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244729-B2 | 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives | NOVARTIS AG (CH) | 2007-07-17 | — | — | US | disclosed |