Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.57 |
| ▸ | ROS1 | P08922 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | BTK | Q06187 | 3/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5405435 | 0.89 | LRRK2 (0.51) | LRRK2ROS1ALKJAK2JAK3 | |
| SCHEMBL5405428 | 0.88 | LRRK2 (0.47) | LRRK2ROS1ALKSYKJAK2 | |
| SCHEMBL5407979 | 0.87 | STK17A (0.46) | LRRK2ROS1ALKJAK2JAK3 | |
| SCHEMBL5416251 | 0.86 | LRRK2 (0.60) | LRRK2ROS1ALKJAK2 | |
| SCHEMBL5414022 | 0.80 | LRRK2 (0.47) | LRRK2ROS1ALKSYKJAK2 | |
| SCHEMBL5408196 | 0.78 | MEN1 (0.54) | LRRK2ROS1ALKJAK2 | |
| SCHEMBL5410626 | 0.77 | MEN1 (0.56) | LRRK2ROS1ALKJAK2 | |
| SCHEMBL5409983 | 0.77 | MEN1 (0.56) | LRRK2ROS1ALKJAK2 | |
| SCHEMBL5411594 | 0.76 | BRD4 (0.58) | LRRK2ALKJAK2 | |
| SCHEMBL5405536 | 0.76 | ALK (0.54) | LRRK2ALKSYKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166599-B2 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2007-01-23 | — | — | US | disclosed |
| US-20050090486-A1 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-04-28 | — | — | US | disclosed |
| US-20030134838-A1 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030134838-A1 | Trisubstituted pyrimidines | APP, PSEN1, BACE1 | LRRK2 619/4885ROS1 2088/4885ALK 3651/4885 |
| US-20050090486-A1 | Trisubstituted pyrimidines | APP, BACE1, PSEN1 | LRRK2 775/4885ROS1 2422/4885ALK 2986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.