Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 8/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5400732 | 0.88 | MC4R (0.76) | MC4RSLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL5411624 | 0.86 | MC4R (0.59) | MC4RSLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL14593473 | 0.86 | MC4R (0.77) | MC4RSLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL14593459 | 0.85 | MC4R (0.62) | MC4RSLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL14593479 | 0.84 | MC4R (0.64) | MC4RSLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL5417823 | 0.79 | MC4R (0.55) | MC4R | |
| SCHEMBL14593470 | 0.78 | MC4R (0.76) | MC4RSLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL14593463 | 0.76 | MC4R (0.61) | MC4RSLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL14593489 | 0.75 | MC4R (0.57) | MC4RSLC6A2SLC6A4KCNH2CYP2D6 | |
| Hydrochloric Acid SCHEMBL5406022 | 0.74 | MC4R (0.50) | MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169777-B2 | Melanocortin receptor agonists | ELI LILLY AND COMPANY (US) | 2007-01-30 | — | — | US | disclosed |
| US-20040116699-A1 | Melanocortin receptor agonists | ELI LILLY AND COMPANY | 2004-06-17 | — | — | US | disclosed |
| EP-1358163-A1 | MELANOCORTIN RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002059095-A1 | MELANOCORTIN RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2002-08-01 | — | — | WO | disclosed |