Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 20/20 | 0.74 |
| ▸ | KDR | P35968 | 8/20 | 0.58 |
| ▸ | INSR | P06213 | 2/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1184724 | 0.89 | PLK1 (0.74) | PLK1KDRINSRPTK2AURKB | |
| SCHEMBL16270765 | 0.89 | PLK1 (0.84) | PLK1KDRINSRPTK2AURKB | |
| Hydrochloric Acid SCHEMBL1184696 | 0.89 | PLK1 (0.73) | PLK1KDRINSRPTK2AURKB | |
| SCHEMBL1183864 | 0.89 | PLK1 (0.73) | PLK1KDRINSRPTK2AURKB | |
| SCHEMBL1184202 | 0.88 | PLK1 (0.80) | PLK1KDRINSRPTK2AURKB | |
| SCHEMBL1184201 | 0.88 | PLK1 (0.80) | PLK1KDRINSRPTK2AURKB | |
| SCHEMBL1183737 | 0.88 | PLK1 (0.79) | PLK1KDRINSRPTK2AURKB | |
| SCHEMBL1883730 | 0.87 | PLK1 (0.71) | PLK1KDRINSRPTK2AURKB | |
| SCHEMBL1184200 | 0.87 | PLK1 (0.87) | PLK1KDRINSRPTK2AURKB | |
| Hydrochloric Acid SCHEMBL1187015 | 0.87 | PLK1 (0.78) | PLK1KDRINSRPTK2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799684-A2 | LACTAM COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006041773-A2 | LACTAM COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-04-20 | — | — | WO | disclosed |