Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 10/20 | 0.73 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | STK17B | O94768 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5413028 | 0.98 | STK17A (0.73) | STK17AMAPTSTK17BMEN1CYP1A2 | |
| SCHEMBL1917009 | 0.94 | STK17A (0.72) | STK17AMAPTSTK17BMEN1CYP1A2 | |
| SCHEMBL5408700 | 0.86 | STK17A (0.80) | STK17AMAPTSTK17BMEN1CYP1A2 | |
| SCHEMBL1917301 | 0.85 | STK17A (0.94) | STK17ASTK17BGSK3BPRKCQ | |
| SCHEMBL1917676 | 0.85 | STK17A (0.78) | STK17AMAPTSTK17BMEN1CYP1A2 | |
| SCHEMBL1916936 | 0.85 | STK17A (0.74) | STK17AMAPTSTK17BMEN1CYP1A2 | |
| SCHEMBL1916898 | 0.85 | STK17A (0.92) | STK17ASTK17BGSK3BPRKCQ | |
| SCHEMBL3284476 | 0.85 | STK17A (0.77) | STK17AMAPTSTK17BMEN1CYP1A2 | |
| SCHEMBL1918919 | 0.85 | STK17A (0.92) | STK17ASTK17BGSK3BPRKCQ | |
| SCHEMBL1917551 | 0.85 | STK17A (0.77) | STK17AMAPTSTK17BMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166599-B2 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2007-01-23 | — | — | US | disclosed |
| US-20050090486-A1 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-04-28 | — | — | US | disclosed |
| US-20030134838-A1 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030134838-A1 | Trisubstituted pyrimidines | APP, PSEN1, BACE1 | STK17A 3301/4885MAPT 13/4885STK17B 3455/4885 |
| US-20050090486-A1 | Trisubstituted pyrimidines | APP, BACE1, PSEN1 | STK17A 3456/4885MAPT 12/4885STK17B 3502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.