Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 4/20 | 0.45 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 8/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 4/20 | 0.40 |
| ▸ | ABL1 | P00519 | 4/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | FES | P07332 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | FER | P16591 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | CSK | P41240 | 1/20 | 0.38 |
| ▸ | ABL2 | P42684 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545439 | 0.92 | MAPK14 (0.44) | RAF1BRAFMAPK14MAP3K20MAP3K7 | |
| SCHEMBL5428304 | 0.90 | RAF1 (0.44) | RAF1BRAFMAPK14MAP3K20MAP3K7 | |
| SCHEMBL546229 | 0.89 | MAPK14 (0.50) | RAF1BRAFMAPK14MAP3K20MAP3K7 | |
| SCHEMBL545423 | 0.88 | MAPK14 (0.49) | RAF1BRAFMAPK14MAP3K20MAP3K7 | |
| SCHEMBL10199733 | 0.88 | KDR (0.42) | RAF1BRAFKDRFLT1 | |
| SCHEMBL10199956 | 0.88 | RAF1 (0.49) | RAF1BRAFKDRFLT1 | |
| SCHEMBL545637 | 0.88 | KDR (0.52) | RAF1BRAFMAPK14MAP3K20MAP3K7 | |
| SCHEMBL545648 | 0.87 | ABL1 (0.58) | BRAFSRCABL1 | |
| SCHEMBL545010 | 0.85 | KDR (0.50) | RAF1BRAFMAPK14MAP3K20MAP3K7 | |
| SCHEMBL546218 | 0.83 | BRAF (0.48) | RAF1BRAFMAPK14MAP3K20KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |
| US-20070149533-A1 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-06-28 | — | — | US | disclosed |
| US-20070149533-A1 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-06-28 | — | — | US | disclosed |
| US-20070149533-A1 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-06-28 | — | — | US | disclosed |
| WO-2007067444-A1 | BICYCLIC COMPOUNDS WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149533-A1 | Bicyclic compounds with kinase inhibitory activity | MAP3K20, MAP3K1, MAP3K5 | RAF1 198/4885BRAF 215/4885MAPK14 278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.