Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 12/20 | 0.34 |
| ▸ | CLK2 | P49760 | 7/20 | 0.34 |
| ▸ | CLK3 | P49761 | 7/20 | 0.34 |
| ▸ | WNT1 | P04628 | 5/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MARK3 | P27448 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8256328 | 0.86 | CSNK1D (0.44) | CSNK1DDYRK1ACLK2CLK3WNT1 | |
| SCHEMBL8255894 | 0.73 | CSNK1D (0.64) | CSNK1DDYRK1ACLK2CLK3WNT1 | |
| SCHEMBL8259055 | 0.72 | CDC7 (0.37) | CSNK1DDYRK1ACLK2CLK3WNT1 | |
| SCHEMBL13876986 | 0.68 | CSNK1D (0.61) | CSNK1DDYRK1ACLK2CLK3WNT1 | |
| SCHEMBL13812056 | 0.68 | CSNK1D (0.51) | CSNK1DDYRK1ACLK2CLK3WNT1 | |
| SCHEMBL5377563 | 0.67 | DYRK1A (0.52) | CSNK1DDYRK1ACLK2CLK3WNT1 | |
| SCHEMBL8257531 | 0.67 | CSNK1D (0.44) | CSNK1DDYRK1ACLK2CLK3WNT1 | |
| SCHEMBL5394703 | 0.66 | CSNK1D (0.53) | CSNK1DDYRK1ACLK2CLK3WNT1 | |
| SCHEMBL5381396 | 0.64 | CSNK1D (0.48) | CSNK1DDYRK1ACLK2CLK3WNT1 | |
| SCHEMBL8252735 | 0.63 | CSNK1D (0.46) | CSNK1DDYRK1ACLK2CLK3WNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211594-B2 | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-05-01 | — | — | US | disclosed |