Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 7/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.50 |
| ▸ | LSS | P48449 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5417065 | 0.80 | LSS (0.50) | CHRM2CHRM1CHRM3LSSCHRNA7 | |
| Fumaric Acid SCHEMBL5417070 | 0.80 | LSS (0.50) | CHRM2CHRM1CHRM3LSSCHRNA7 | |
| SCHEMBL4204692 | 0.79 | LSS (0.55) | LSSCHRNA7 | |
| Fumaric Acid SCHEMBL5420571 | 0.78 | CHRNA7 (0.50) | CHRM2CHRM1CHRM3LSSCHRNA7 | |
| Fumaric Acid SCHEMBL5420562 | 0.78 | CHRNA7 (0.50) | CHRM2CHRM1CHRM3LSSCHRNA7 | |
| SCHEMBL5431557 | 0.77 | CHRNA7 (0.53) | CHRM2CHRM1CHRM3LSSCHRNA7 | |
| SCHEMBL5650196 | 0.77 | LSS (0.49) | CHRM2CHRM1CHRM3LSSCHRNA7 | |
| Fumaric Acid SCHEMBL1020193 | 0.76 | LSS (0.53) | CHRM2CHRM1CHRM3LSSCHRNA7 | |
| SCHEMBL5650254 | 0.75 | LSS (0.57) | CHRM2CHRM1CHRM3LSSCHRNA7 | |
| SCHEMBL5408455 | 0.75 | CHRNA7 (0.53) | CHRM2CHRM1CHRM3LSSCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309699-B2 | 3-Quinuclidinyl amino-substituted biaryl derivatives | ABBOTT LABORATORIES (US) | 2007-12-18 | — | — | US | disclosed |
| US-20070275975-A1 | 3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES | JI JIANGUO | 2007-11-29 | — | — | US | disclosed |
| US-20050159597-A1 | 3-Quinuclidinyl amino-substituted biaryl derivatives | ABBOTT LABORATORIES | 2005-07-21 | — | — | US | disclosed |
| US-20050137203-A1 | 3-quinuclidinyl amino-substituted biaryl derivatives | ABBOTT LABORATORIES | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159597-A1 | 3-Quinuclidinyl amino-substituted biaryl derivatives | CHRNA7, CHRNA9, CHRNA1 | CHRM2 35/4885CHRM1 36/4885CHRM3 16/4885 |
| US-20070275975-A1 | 3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES | CHRNA7, CHRNA9, CHRNA1 | CHRM2 35/4885CHRM1 36/4885CHRM3 16/4885 |
| US-20050137203-A1 | 3-quinuclidinyl amino-substituted biaryl derivatives | CHRNA9, CHRNA7, CHRNA1 | CHRM2 34/4885CHRM1 37/4885CHRM3 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.