Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 6/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.53 |
| ▸ | TSHR | P16473 | 6/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.52 |
| ▸ | USP2 | O75604 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5428081 | 0.95 | CCR8 (0.61) | CCR8KCNH2CYP3A4TSHRHIF1A | |
| SCHEMBL5405336 | 0.95 | CCR8 (0.67) | CCR8KCNH2CYP3A4TSHRHIF1A | |
| Trifluoroacetic Acid SCHEMBL5432400 | 0.94 | CYP2D6 (0.57) | CCR8KCNH2CYP3A4TSHRHIF1A | |
| SCHEMBL5405956 | 0.90 | CCR8 (0.67) | CCR8KCNH2CYP3A4TSHRCYP2D6 | |
| Trifluoroacetic Acid SCHEMBL5431983 | 0.89 | CCR8 (0.60) | CCR8KCNH2CYP3A4TSHRHIF1A | |
| Trifluoroacetic Acid SCHEMBL5432494 | 0.89 | CCR8 (0.60) | CCR8KCNH2CYP3A4TSHRHIF1A | |
| Trifluoroacetic Acid SCHEMBL5428094 | 0.89 | CYP2D6 (0.67) | CCR8KCNH2CYP3A4TSHRHIF1A | |
| Trifluoroacetic Acid SCHEMBL5436904 | 0.89 | CCR8 (0.66) | CCR8KCNH2CYP3A4TSHRHIF1A | |
| Trifluoroacetic Acid SCHEMBL5426520 | 0.89 | CCR8 (0.66) | CCR8KCNH2CYP3A4TSHRHIF1A | |
| Trifluoroacetic Acid SCHEMBL5434991 | 0.89 | CCR8 (0.57) | CCR8KCNH2CYP3A4TSHRHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249648-A1 | Novel Diazaspiroalkanes and Their Use for Treatment of Ccr8 Mediated Diseases | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | US | disclosed |
| EP-1678178-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | AstraZeneca AB (SE) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040167-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249648-A1 | Novel Diazaspiroalkanes and Their Use for Treatment of Ccr8 Mediated Diseases | CCR8, CCR1, CCR10 | CCR8 1/4885KCNH2 2793/4885CYP3A4 3598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.