Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | GCK | P35557 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5430848 | 0.76 | KMT2A (0.58) | KMT2AMEN1TSHRSMN1; SMN2LMNA | |
| SCHEMBL5443657 | 0.71 | KMT2A (0.54) | KMT2AMEN1TSHRSMN1; SMN2LMNA | |
| SCHEMBL27824621 | 0.71 | PLAU (0.48) | KMT2AMEN1TSHRPLAUSMN1; SMN2 | |
| SCHEMBL5335728 | 0.70 | KMT2A (0.53) | KMT2AMEN1TSHRSMN1; SMN2LMNA | |
| SCHEMBL30448050 | 0.70 | BRAF (0.52) | KMT2AMEN1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL28471698 | 0.70 | BRAF (0.52) | KMT2AMEN1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL27824608 | 0.69 | GCK (0.48) | KMT2AMEN1TSHRPLAUSMN1; SMN2 | |
| SCHEMBL14284584 | 0.69 | GRM4 (0.52) | KMT2AMEN1SMN1; SMN2HTTMAPT | |
| SCHEMBL10294799 | 0.69 | KMT2A (0.78) | KMT2AMEN1TSHRPLAUSMN1; SMN2 | |
| SCHEMBL27824617 | 0.69 | PLAU (0.51) | KMT2AMEN1PLAUSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076474-A1 | NOVEL SUBSTITUTED PYRIDINYLOXY AND PYRIMIDINYLOXY AMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | KALYPSYS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |