Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 15/20 | 0.65 |
| ▸ | AKT2 | P31751 | 1/20 | 0.58 |
| ▸ | CLK2 | P49760 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4130065 | 0.90 | AKT2 (0.68) | HSP90AA1AKT2CLK2DYRK1ACLK4 | |
| SCHEMBL5430208 | 0.83 | HSP90AA1 (0.73) | HSP90AA1AKT2CLK2DYRK1ACLK4 | |
| SCHEMBL5433505 | 0.81 | HSP90AA1 (0.70) | HSP90AA1AKT2CLK2DYRK1ACLK4 | |
| SCHEMBL5435172 | 0.81 | AKT2 (0.81) | HSP90AA1AKT2CLK2DYRK1ACLK4 | |
| SCHEMBL5433706 | 0.80 | HSP90AA1 (0.64) | HSP90AA1AKT2CLK2DYRK1ACLK4 | |
| SCHEMBL5434927 | 0.79 | HSP90AA1 (1.00) | HSP90AA1AKT2CLK2DYRK1ACLK4 | |
| SCHEMBL5433525 | 0.79 | HSP90AA1 (0.67) | HSP90AA1AKT2CLK2DYRK1ACLK4 | |
| SCHEMBL5434334 | 0.78 | HSP90AA1 (0.65) | HSP90AA1AKT2CLK2DYRK1ACLK4 | |
| SCHEMBL4139002 | 0.78 | HSP90AA1 (0.75) | HSP90AA1AKT2CLK2DYRK1ACLK4 | |
| SCHEMBL5431580 | 0.77 | HSP90AA1 (1.00) | HSP90AA1AKT2CLK2DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070105862-A1 | Heat-shock protein binders | ABBOTT LABORATORIES | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105862-A1 | Heat-shock protein binders | HSP90AB1, HSP90AB2P, HSP90B1 | HSP90AA1 5/4885AKT2 1478/4885CLK2 2419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.