Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 8/20 | 0.59 |
| ▸ | TSHR | P16473 | 5/20 | 0.56 |
| ▸ | USP2 | O75604 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.52 |
| ▸ | CCR8 | P51685 | 7/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5399254 | 0.95 | CYP2D6 (0.62) | CYP2D6TSHRUSP2SMN1; SMN2CHRM2 | |
| Trifluoroacetic Acid SCHEMBL5434658 | 0.92 | CYP2D6 (0.57) | CYP2D6TSHRUSP2SMN1; SMN2CHRM2 | |
| Trifluoroacetic Acid SCHEMBL5431615 | 0.91 | CYP2D6 (0.58) | CYP2D6TSHRUSP2SMN1; SMN2CHRM2 | |
| Trifluoroacetic Acid SCHEMBL5431336 | 0.89 | CCR8 (0.62) | CYP2D6TSHRUSP2SMN1; SMN2CHRM2 | |
| Trifluoroacetic Acid SCHEMBL5433719 | 0.88 | USP2 (0.67) | CYP2D6TSHRUSP2SMN1; SMN2CHRM2 | |
| Trifluoroacetic Acid SCHEMBL5439858 | 0.87 | CYP2D6 (0.65) | CYP2D6TSHRUSP2SMN1; SMN2CHRM2 | |
| Trifluoroacetic Acid SCHEMBL5430883 | 0.87 | CYP2D6 (0.60) | CYP2D6TSHRUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL5431253 | 0.87 | CYP2D6 (0.59) | CYP2D6TSHRUSP2SMN1; SMN2CHRM2 | |
| Trifluoroacetic Acid SCHEMBL5428831 | 0.86 | CYP2D6 (0.58) | CYP2D6TSHRUSP2SMN1; SMN2CHRM2 | |
| Trifluoroacetic Acid SCHEMBL5428508 | 0.85 | TSHR (0.58) | CYP2D6TSHRUSP2SMN1; SMN2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249648-A1 | Novel Diazaspiroalkanes and Their Use for Treatment of Ccr8 Mediated Diseases | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249648-A1 | Novel Diazaspiroalkanes and Their Use for Treatment of Ccr8 Mediated Diseases | CCR8, CCR1, CCR10 | CYP2D6 1764/4885TSHR 3697/4885USP2 1826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.