SCHEMBL543475

SCHEMBL543475

Nc1ncnc2c1ncn2[C@H]1CC(O)[C@@H](COP(=O)(O)O)O1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.81
ENPP1 P22413 3/20 0.76
P2RY1 P47900 2/20 0.76
DNPH1 O43598 1/20 0.70
PRKAB2 O43741 1/20 0.70
TRPM2 O94759 1/20 0.70
LDHA P00338 1/20 0.70
ADRB2 P07550 1/20 0.70
FBP1 P09467 1/20 0.70
SRC P12931 1/20 0.70
ADORA1 P30542 1/20 0.70
P2RY2 P41231 1/20 0.70
PRKAG1 P54619 1/20 0.70
PRKAA2 P54646 1/20 0.70
PDE4D Q08499 1/20 0.70
KCNH2 Q12809 1/20 0.70
PRKAA1 Q13131 1/20 0.70
PDE3A Q14432 1/20 0.70
SMN1; SMN2 Q16637 1/20 0.70
TAS1R3 Q7RTX0 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20341113 1.00 POLB (0.81) POLBENPP1P2RY1DNPH1PRKAB2
SCHEMBL7882477 1.00 POLB (0.81) POLBENPP1P2RY1DNPH1PRKAB2
SCHEMBL18785113 1.00 POLB (0.81) POLBENPP1P2RY1DNPH1PRKAB2
SCHEMBL11927745 1.00 POLB (0.81) POLBENPP1P2RY1DNPH1PRKAB2
SCHEMBL4546151 1.00 POLB (0.81) POLBENPP1P2RY1DNPH1PRKAB2
SCHEMBL48174 1.00 POLB (0.81) POLBENPP1P2RY1DNPH1PRKAB2
Water SCHEMBL112387 0.99 POLB (0.79) POLBENPP1P2RY1DNPH1PRKAB2
Triphosphate SCHEMBL27892354 0.96 POLB (0.81) POLBENPP1P2RY1DNPH1PRKAB2
SCHEMBL24538794 0.93 POLB (0.77) POLBENPP1P2RY1DNPH1PRKAB2
SCHEMBL8742200 0.93 POLB (0.77) POLBENPP1P2RY1DNPH1PRKAB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118109537-A Application of halogenating enzyme in catalytic synthesis of 2' -halogenated nucleoside monophosphate 香港中文大学(深圳) 2024-05-31 CN claimed
US-20220401617-A1 ADHESIVE COMPOSITIONS COMPRISING THERAPEUTICS REVBIO INC (US) 2022-12-22 US claimed
EP-4054548-A1 ADHESIVE COMPOSITIONS COMPRISING THERAPEUTICS RevBio, Inc. (US) 2022-09-14 EP claimed
US-8110676-B2 Prodrugs activated by RNA-dependent DNA-polymerases PROTERA S.R.L. (IT) 2012-02-07 US claimed
US-20050136673-A1 CMP slurry XU WEN-QING (US) 2005-06-23 US claimed
WO-2005014746-A1 CMP SLURRY NYACOL NANO TECHNOLOGIES, INC. (US) 2005-02-17 WO claimed
US-20050028450-A1 CMP slurry XU WEN-QING (US) 2005-02-10 US claimed
US-20250049488-A1 DEVICES AND METHODS FOR BONE FIXATION REVBIO INC (US) 2025-02-13 US disclosed
US-20240368682-A1 SYSTEMS AND METHODS FOR CLONAL REPLICATION AND AMPLIFICATION OF NUCLEIC ACID MOLECULES FOR GENOMIC AND THERAPEUTIC APPLICATIONS REDVAULT BIOSCIENCES LP (US) 2024-11-07 US disclosed
EP-4447833-A2 DEVICES AND METHODS FOR BONE FIXATION RevBio, Inc. (US) 2024-10-23 EP disclosed
US-20240180625-A1 IMAGE GUIDED DELIVERY OF COMPOSITIONS AND RELATED METHODS REVBIO INC (US) 2024-06-06 US disclosed
CN-118109537-A Application of halogenating enzyme in catalytic synthesis of 2' -halogenated nucleoside monophosphate 香港中文大学(深圳) 2024-05-31 CN disclosed
US-20230329755-A1 BONE FLAP FIXATION DEVICE REVBIO INC (US) 2023-10-19 US disclosed
EP-0604409-A4 COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION. ISIS PHARMACEUTICALS INC (US) 1996-06-12 EP disclosed
WO-1995007364-A1 NUCLEIC ACID LIGANDS AND IMPROVED METHODS FOR PRODUCING THE SAME NEXSTAR PHARMACEUTICALS, INC. (US) 1995-03-16 WO disclosed
EP-0604409-A1 COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 1994-07-06 EP disclosed
EP-0519053-A4 NUCLEIC ACID AMPLIFICATION WITH DNA-DEPENDENT RNA POLYMERASE ACTIVITY OF RNA REPLICASES 1993-03-31 EP disclosed
EP-0519053-A1 NUCLEIC ACID AMPLIFICATION WITH DNA-DEPENDENT RNA POLYMERASE ACTIVITY OF RNA REPLICASES. PROMEGA CORP (US) 1992-12-23 EP disclosed
WO-1992012261-A1 NUCLEIC ACID AMPLIFICATION WITH DNA-DEPENDENT RNA POLYMERASE ACTIVITY OF RNA REPLICASES PROMEGA CORPORATION (US) 1992-07-23 WO disclosed
WO-1991010671-A1 COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 1991-07-25 WO disclosed