Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 16/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 15/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 15/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1407964 | 0.87 | DPP4 (0.47) | DPP4DPP8DPP9 | |
| SCHEMBL1408154 | 0.77 | DPP4 (0.46) | DPP4DPP8DPP9 | |
| SCHEMBL1407499 | 0.75 | DPP4 (0.66) | DPP4DPP8DPP9 | |
| SCHEMBL1408018 | 0.75 | DPP4 (0.49) | DPP4DPP8DPP9 | |
| SCHEMBL1407840 | 0.73 | DPP4 (0.54) | DPP4DPP8DPP9 | |
| SCHEMBL1407767 | 0.64 | DPP4 (0.67) | DPP4DPP8DPP9 | |
| SCHEMBL293409 | 0.64 | GSK3A (0.44) | DPP4DPP8DPP9GSK3AGSK3B | |
| SCHEMBL1408126 | 0.63 | DPP4 (0.53) | DPP4DPP8DPP9 | |
| SCHEMBL1407624 | 0.62 | DPP4 (0.49) | DPP4DPP8DPP9 | |
| SCHEMBL1408124 | 0.62 | DPP4 (0.48) | DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836206-A1 | AZOLOPYRIMIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS | Bristol-Myers Squibb Company (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006071752-A1 | AZOLOPYRIMIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-06 | — | — | WO | disclosed |