Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 5/20 | 0.70 |
| ▸ | TSHR | P16473 | 3/20 | 0.70 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.67 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.67 |
| ▸ | CCR8 | P51685 | 5/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5428856 | 0.92 | TSHR (0.70) | CYP2D6TSHRCHRM2CHRM3CCR8 | |
| Trifluoroacetic Acid SCHEMBL5431418 | 0.90 | CHRM2 (0.65) | CYP2D6TSHRCHRM2CHRM3CCR8 | |
| Trifluoroacetic Acid SCHEMBL5426142 | 0.90 | CCR8 (0.66) | CYP2D6TSHRCHRM2CHRM3CCR8 | |
| Trifluoroacetic Acid SCHEMBL5435327 | 0.87 | CHRM2 (0.89) | CYP2D6TSHRCHRM2CHRM3CCR8 | |
| Trifluoroacetic Acid SCHEMBL5436006 | 0.85 | CHRM2 (0.89) | CYP2D6TSHRCHRM2CHRM3CCR8 | |
| Trifluoroacetic Acid SCHEMBL5434780 | 0.85 | USP2 (0.73) | CYP2D6TSHRCHRM2CHRM3CCR8 | |
| Trifluoroacetic Acid SCHEMBL5441625 | 0.84 | CYP2D6 (0.62) | CYP2D6TSHRCHRM2CHRM3CCR8 | |
| Trifluoroacetic Acid SCHEMBL5433513 | 0.84 | CYP2D6 (0.63) | CYP2D6TSHRCCR8KCNH2MEN1 | |
| Trifluoroacetic Acid SCHEMBL4189677 | 0.84 | CCR8 (0.91) | CYP2D6TSHRCHRM2CHRM3CCR8 | |
| SCHEMBL5437394 | 0.83 | KMT2A (0.54) | CYP2D6TSHRCHRM2CHRM3CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249648-A1 | Novel Diazaspiroalkanes and Their Use for Treatment of Ccr8 Mediated Diseases | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | US | disclosed |
| EP-1678178-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | AstraZeneca AB (SE) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040167-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249648-A1 | Novel Diazaspiroalkanes and Their Use for Treatment of Ccr8 Mediated Diseases | CCR8, CCR1, CCR10 | CYP2D6 1764/4885TSHR 3697/4885CHRM2 581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.