Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.76 |
| ▸ | CSF1R | P07333 | 1/20 | 0.68 |
| ▸ | KDR | P35968 | 2/20 | 0.62 |
| ▸ | STK10 | O94804 | 1/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.62 |
| ▸ | YES1 | P07947 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.62 |
| ▸ | BCR | P11274 | 1/20 | 0.62 |
| ▸ | FLT1 | P17948 | 1/20 | 0.62 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.62 |
| ▸ | WEE1 | P30291 | 1/20 | 0.62 |
| ▸ | ABL2 | P42684 | 1/20 | 0.62 |
| ▸ | NEK3 | P51956 | 1/20 | 0.62 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.62 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.62 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.62 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772771 | 1.00 | EGFR (0.76) | EGFRCSF1RKDRSTK10MAP4K4 | |
| SCHEMBL4764025 | 0.90 | EGFR (0.81) | EGFRCSF1RKDRHDAC3HDAC4 | |
| SCHEMBL3845085 | 0.89 | EGFR (0.80) | EGFRCSF1RKDRSTK10MAP4K4 | |
| SCHEMBL28750275 | 0.89 | EGFR (0.80) | EGFRCSF1RKDRSTK10MAP4K4 | |
| SCHEMBL27603011 | 0.88 | EGFR (0.72) | EGFRCSF1RKDRSTK10MAP4K4 | |
| SCHEMBL4772754 | 0.88 | EGFR (0.72) | EGFRCSF1RKDRSTK10MAP4K4 | |
| SCHEMBL27603143 | 0.86 | EGFR (0.70) | EGFRCSF1RKDRSTK10MAP4K4 | |
| SCHEMBL4764333 | 0.86 | EGFR (0.70) | EGFRCSF1RKDRSTK10MAP4K4 | |
| SCHEMBL4772881 | 0.86 | EGFR (0.66) | EGFRCSF1RKDRERBB2HDAC3 | |
| SCHEMBL27585537 | 0.85 | EGFR (0.73) | EGFRCSF1RKDRSTK10MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101560214-B | 4-amino-6-phenyl-pyrrolo[2, 3-d]pyrimidine derivatives | NOVARTIS AG | 2011-05-25 | — | — | CN | disclosed |
| CN-101560214-A | 4-amino-6-phenyl-pyrrolo[2, 3-d]pyrimidine derivatives | NOVARTIS AG (CH) | 2009-10-21 | — | — | CN | disclosed |
| US-7244729-B2 | 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives | NOVARTIS AG (CH) | 2007-07-17 | — | — | US | disclosed |
| CN-1538847-A | 4-amino-6-phenyl-pyrrolo [2, 3-d ] pyrimidine derivatives | ��˹��ŵ�� | 2004-10-20 | — | — | CN | disclosed |