Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | GABRP | O00591 | 2/20 | 0.41 |
| ▸ | GABRD | O14764 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5439157 | 0.86 | HSP90AA1 (0.58) | HSP90AA1HSD17B10PKMAKT2CLK2 | |
| SCHEMBL5431271 | 0.85 | HSP90AA1 (0.57) | HSP90AA1HSD17B10PKMKDM4EALDH1A1 | |
| SCHEMBL5440403 | 0.85 | HSP90AA1 (0.69) | HSP90AA1KDM4EAKT2CLK2DYRK1A | |
| SCHEMBL5430292 | 0.84 | HSP90AA1 (0.64) | HSP90AA1ALDH1A1AKT2CLK2DYRK1A | |
| SCHEMBL5440392 | 0.82 | HSP90AA1 (0.62) | HSP90AA1AKT2CLK2DYRK1ACLK4 | |
| SCHEMBL5440420 | 0.81 | HSP90AA1 (0.76) | HSP90AA1KDM4EAKT2CLK2DYRK1A | |
| SCHEMBL5438573 | 0.81 | HSP90AA1 (0.60) | HSP90AA1KDM4EAKT2CLK2DYRK1A | |
| SCHEMBL5430102 | 0.81 | HSP90AA1 (0.63) | HSP90AA1KDM4EAKT2CLK2DYRK1A | |
| SCHEMBL5437772 | 0.80 | HSP90AA1 (0.69) | HSP90AA1KDM4EHPGDAKT2CLK2 | |
| SCHEMBL5433928 | 0.80 | HSP90AA1 (0.62) | HSP90AA1AKT2CLK2DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070105862-A1 | Heat-shock protein binders | ABBOTT LABORATORIES | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105862-A1 | Heat-shock protein binders | HSP90AB1, HSP90AB2P, HSP90B1 | HSP90AA1 5/4885HSD17B10 1671/4885PKM 3927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.