Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.58 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | POLB | P06746 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 7/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5442110 | 1.00 | KMT2A (0.58) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL5454199 | 0.87 | KMT2A (0.62) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL5454202 | 0.87 | KMT2A (0.62) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL14444419 | 0.83 | KMT2A (0.61) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL13056449 | 0.82 | KMT2A (0.60) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL5444385 | 0.81 | GAA (0.68) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL5444388 | 0.81 | GAA (0.68) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL14444650 | 0.80 | KMT2A (0.58) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL12632696 | 0.80 | KMT2A (0.58) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL5452845 | 0.80 | KMT2A (0.55) | KMT2AMEN1POLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070037846-A1 | Pyrazolidinedione derivatives | ACTELION PHARMACEUTICALS, LTD. (CH) | 2007-02-15 | — | — | US | claimed |
| CN-1812782-A | Pyrazolidinedione derivatives and their use as platelet aggregation inhibitors | ACTELION PHARMACEUTICALS LTD (CH) | 2006-08-02 | — | — | CN | claimed |
| US-20070040151-A1 | Two-component initiator system (amine-free) with very good storage stability and particular suitability for acid systems | HERAEUS KULZER GMBH (DE) | 2007-02-22 | — | — | US | disclosed |
| US-20070037846-A1 | Pyrazolidinedione derivatives | ACTELION PHARMACEUTICALS, LTD. (CH) | 2007-02-15 | — | — | US | disclosed |
| CN-1812782-A | Pyrazolidinedione derivatives and their use as platelet aggregation inhibitors | ACTELION PHARMACEUTICALS LTD (CH) | 2006-08-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037846-A1 | Pyrazolidinedione derivatives | P2RY1, P2RY4, P2RY2 | KMT2A 4413/4885MEN1 2963/4885POLB 4499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.