Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5438487 | 0.90 | HDAC6 (0.49) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL5438655 | 0.84 | HDAC6 (0.54) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL5453441 | 0.83 | HDAC6 (0.54) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| Oxalic Acid SCHEMBL5444728 | 0.80 | HDAC6 (0.51) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL19029094 | 0.76 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL5440808 | 0.75 | TP53 (0.46) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL19029312 | 0.72 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL446323 | 0.71 | HDAC6 (0.58) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL21352507 | 0.70 | HDAC6 (0.67) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| Trifluoroacetic Acid SCHEMBL21352506 | 0.70 | HDAC6 (0.84) | HDAC6HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135485-A1 | Novel mch receptor antagonists | ELI LILLY AND COMPANY | 2007-06-14 | — | — | US | disclosed |
| US-20070135485-A1 | Novel mch receptor antagonists | ELI LILLY AND COMPANY | 2007-06-14 | — | — | US | disclosed |
| US-20070135485-A1 | Novel mch receptor antagonists | ELI LILLY AND COMPANY | 2007-06-14 | — | — | US | disclosed |
| EP-1723126-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005040157-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135485-A1 | Novel mch receptor antagonists | MCHR1, MCHR2, MC1R | HDAC6 1655/4885HDAC3 2603/4885HDAC1 2127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.