Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.79 |
| ▸ | MEN1 | O00255 | 9/20 | 0.79 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PTPRE | P23469 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5443025 | 0.92 | MEN1 (0.79) | KMT2AMEN1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL5454421 | 0.90 | KMT2A (0.79) | KMT2AMEN1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL5435544 | 0.89 | KMT2A (0.77) | KMT2AMEN1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL5455997 | 0.89 | KMT2A (0.77) | KMT2AMEN1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL5435545 | 0.89 | KMT2A (0.77) | KMT2AMEN1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL5444310 | 0.88 | KMT2A (1.00) | KMT2AMEN1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL5442511 | 0.86 | MEN1 (0.73) | KMT2AMEN1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL5450994 | 0.85 | KMT2A (0.74) | KMT2AMEN1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL5436740 | 0.84 | MEN1 (0.80) | KMT2AMEN1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL3467861 | 0.83 | MEN1 (0.72) | KMT2AMEN1NPC1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | MERCK PATENT GMBH (DE) | 2007-08-16 | — | — | US | claimed |
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | MERCK PATENT GMBH (DE) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | RAF1, ARAF, JAK1 | KMT2A 1865/4885MEN1 1756/4885NPC1 3509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.