Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HPN | P05981 | 1/20 | 0.54 |
| ▸ | PTPRE | P23469 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 4/20 | 0.52 |
| ▸ | RAF1 | P04049 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5450981 | 0.90 | MAPT (0.59) | MAPTL3MBTL1HPNPTPREBLM | |
| SCHEMBL5438309 | 0.86 | KMT2A (0.70) | L3MBTL1BLMCA1CA2CA7 | |
| SCHEMBL5446284 | 0.85 | MEN1 (0.59) | MAPTL3MBTL1BLMCA1CA2 | |
| SCHEMBL5442863 | 0.85 | MAPT (0.58) | MAPTL3MBTL1HPNPTPRERAF1 | |
| SCHEMBL5442574 | 0.84 | MAPT (0.58) | MAPTL3MBTL1HPNPTPREBRAF | |
| SCHEMBL5444273 | 0.83 | HPN (0.76) | MAPTL3MBTL1HPNPTPREMEN1 | |
| SCHEMBL5435664 | 0.82 | MAPT (0.59) | MAPTL3MBTL1HPNPTPREMEN1 | |
| SCHEMBL5449666 | 0.81 | MAPT (0.59) | MAPTL3MBTL1HPNPTPREMEN1 | |
| SCHEMBL5447931 | 0.81 | BLM (0.57) | MAPTL3MBTL1BLMCA1CA2 | |
| SCHEMBL5443077 | 0.80 | HPN (0.64) | MAPTL3MBTL1HPNPTPREMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | MERCK PATENT GMBH (DE) | 2007-08-16 | — | — | US | claimed |
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | MERCK PATENT GMBH (DE) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | RAF1, ARAF, JAK1 | MAPT 3983/4885L3MBTL1 1823/4885HPN 4058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.