Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.44 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.42 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | GPR183 | P32249 | 1/20 | 0.42 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11094959 | 0.98 | SLC6A2 (0.48) | SLC6A2TAAR1CSNK1ETNNC1S1PR1 | |
| SCHEMBL28713655 | 0.98 | SLC6A2 (0.48) | SLC6A2TAAR1CSNK1ETNNC1S1PR1 | |
| SCHEMBL11097970 | 0.98 | SLC6A2 (0.48) | SLC6A2TAAR1CSNK1ETNNC1S1PR1 | |
| SCHEMBL9329228 | 0.98 | SLC6A2 (0.48) | SLC6A2TAAR1CSNK1ETNNC1S1PR1 | |
| SCHEMBL9180309 | 0.98 | SLC6A2 (0.48) | SLC6A2TAAR1CSNK1ETNNC1S1PR1 | |
| Hydrochloric Acid SCHEMBL6850888 | 0.96 | SLC6A2 (0.47) | SLC6A2TAAR1CSNK1ETNNC1S1PR1 | |
| SCHEMBL27893438 | 0.96 | SLC6A2 (0.50) | SLC6A2TAAR1CSNK1ETNNC1S1PR1 | |
| SCHEMBL6056161 | 0.95 | SLC6A2 (0.48) | SLC6A2TAAR1CSNK1ETNNC1S1PR1 | |
| SCHEMBL29107063 | 0.95 | SLC6A2 (0.48) | SLC6A2TAAR1CSNK1ETNNC1S1PR1 | |
| SCHEMBL19253988 | 0.95 | SLC6A2 (0.48) | SLC6A2TAAR1CSNK1ETNNC1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254320-A1 | Method and Kit for Detecting Listeria Spp. | OLSTEIN ALAN | 2007-11-01 | — | — | US | disclosed |
| WO-2005040754-A2 | METHOD AND KIT FOR DETECTING LISTERIA spp. | PARADIGM DIAGNOSTICS, INC. (US) | 2005-05-06 | — | — | WO | disclosed |
| US-5145772-A | FLUOROPHORES | TROPIX, INC. (US) | 1992-09-08 | — | — | US | disclosed |