Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL735636 | 0.86 | PIK3CD (0.42) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL734119 | 0.83 | PIK3CD (0.46) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL733237 | 0.83 | PIK3CG (0.51) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL733233 | 0.83 | PIK3CD (0.47) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL733544 | 0.81 | PIK3CD (0.47) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL1425911 | 0.81 | PIK3CG (0.56) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL734097 | 0.81 | PIK3CG (0.51) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL27743792 | 0.80 | PIK3CD (0.46) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL733812 | 0.79 | PIK3CD (0.44) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL733438 | 0.77 | PIK3CD (0.46) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070238718-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070238718-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | CYP3A43, CYP3A5, UGT1A3 | PIK3CD 3955/4885PIK3R1 4186/4885PIK3CG 4371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.