Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | HTR5A | P47898 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | OGA | O60502 | 5/20 | 0.46 |
| ▸ | IDH1 | O75874 | 5/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5454672 | 0.84 | HRH4 (0.50) | ADRA2BADRA2CSLC6A2HRH2HTR1D | |
| SCHEMBL5454465 | 0.81 | HRH4 (0.49) | ADRA2BADRA2CSLC6A2HRH2HTR1D | |
| SCHEMBL5444558 | 0.78 | HRH4 (0.51) | HRH4MKNK1ROCK2 | |
| SCHEMBL26708280 | 0.75 | CXCR4 (0.63) | ADRA2BADRA2CSLC6A2HRH2HTR1D | |
| SCHEMBL847908 | 0.74 | HRH4 (0.66) | ADRA2BADRA2CSLC6A2HRH2HTR1D | |
| SCHEMBL1588414 | 0.74 | HRH4 (0.81) | ADRA2BADRA2CSLC6A2HRH2HTR1D | |
| Hydrochloric Acid SCHEMBL27538719 | 0.73 | HRH4 (0.64) | ADRA2BADRA2CSLC6A2HRH2HTR1D | |
| SCHEMBL8349470 | 0.71 | OGA (0.57) | ADRA2BADRA2CSLC6A2HRH2HTR1D | |
| SCHEMBL12703055 | 0.70 | HRH4 (0.56) | ADRA2BADRA2CSLC6A2HRH2HTR1D | |
| SCHEMBL1588714 | 0.69 | HRH4 (0.69) | ADRA2BADRA2CSLC6A2HRH2HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070037790-A1 | Bicyclo-pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2007-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037790-A1 | Bicyclo-pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K15, MAP3K7, MAP3K19 | ADRA2B 3757/4885ADRA2C 3472/4885SLC6A2 4873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.