Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.57 |
| ▸ | RAF1 | P04049 | 8/20 | 0.57 |
| ▸ | KDR | P35968 | 12/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL345995 | 0.81 | BRAF (0.63) | BRAFRAF1KDR | |
| SCHEMBL345996 | 0.81 | BRAF (0.63) | BRAFRAF1KDR | |
| SCHEMBL14493322 | 0.80 | BRAF (0.59) | BRAFRAF1KDR | |
| SCHEMBL545665 | 0.80 | BRAF (0.60) | BRAFRAF1KDR | |
| SCHEMBL4679479 | 0.79 | BRAF (0.61) | BRAFRAF1KDR | |
| SCHEMBL10200879 | 0.79 | BRAF (0.61) | BRAFRAF1KDR | |
| SCHEMBL461378 | 0.79 | BRAF (0.64) | BRAFRAF1KDR | |
| SCHEMBL345458 | 0.79 | BRAF (0.64) | BRAFRAF1KDR | |
| SCHEMBL545326 | 0.77 | BRAF (0.83) | BRAFRAF1KDR | |
| SCHEMBL545512 | 0.75 | NR1H2 (0.54) | BRAFRAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |