Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.61 |
| ▸ | RPTOR | Q8N122 | 8/20 | 0.61 |
| ▸ | MLST8 | Q9BVC4 | 8/20 | 0.61 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.61 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.61 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29522148 | 0.85 | MTOR (0.69) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL138187 | 0.85 | MTOR (0.69) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL17470878 | 0.83 | MTOR (0.74) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL138636 | 0.82 | MTOR (0.80) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL29522404 | 0.81 | MTOR (1.00) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL135886 | 0.81 | MTOR (1.00) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL29543291 | 0.80 | MTOR (0.74) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL138618 | 0.80 | MTOR (0.74) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL138262 | 0.80 | MTOR (0.66) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL29522102 | 0.80 | MTOR (0.88) | MTORPIK3CARPTORMLST8RICTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110578-B2 | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway | SIGNAL PHARMACEUTICALS, LLC (US) | 2012-02-07 | — | — | US | claimed |